Iziphumo eziqhelekileyo zecala ziquka isicaphucaphu kunye ne-rash [4], kwaye inokunyusa umngcipheko we-candidiasis; Ukuba idityaniswe ne-clavulanic acid (eyi-amoxicillin clavulanic acid potassium), kuya kubakho iziphumo ebezingalindelekanga zorhudo [5]. Musa ukusebenzisa iziyobisi kubantu abachasene ne-penicillin; Izigulane ezinokusilela kwezintso zingathatha le mveliso, kodwa umthamo kufuneka uncitshiswe. Ukuthatha iyeza ngexesha lokukhulelwa kunye nokuncancisa akubonisi bungozi ngoku [4].

I-Amoxicillin yadweliswa kwi-1972 [6]. Eli chiza lidweliswe kuluhlu lweWorld Health Organisation lwamachiza ayimfuneko, lelinye lamachiza ayimfuneko kwinkqubo yezonyango [7] kunye nelona antibiotic lisetyenziswa kakhulu kubantwana [8]. IAmoxicillin yeyeyeza lenzululwazi [4]. Ixabiso lehoseyile yeyeza ngalinye liphakathi kwe-0.02 kunye ne-0.05 USD [9]. EUnited States, unyango lweentsuku ezilishumi luxabisa malunga nee-$16 [4].

Amoxicillin BP

Amoxicillin 250 mg capsules

umgaqo-nkqubo

I-Amoxicillin isebenza ngokuthintela ukuhlanganiswa kweendonga zeeseli zebhaktheriya. Ithintela unxibelelwano phakathi kwamatyathanga epolymer e-peptidoglycan angawona macandelo aphambili eludongeni lweeseli ze-Gram-positive bacteria kunye ne-Gram-negative bacteria.

isiphumo esiyingozi

Iziphumo ebezingalindelekanga ziquka isicaphucaphu, ukugabha, ukucaphuka kunye ne-antibiotic colitis, kunye nohudo lungenzeka. Kwiimeko ezinqabileyo, iirekhodi zonyango zibonisa ukuba imiphumo emibi ibandakanya utshintsho lwengqondo, isiyezi, ukudideka kwengqondo, ukuxhalaba, kunye ne-paranoia (uvakalelo ekukhanyeni, isandi kunye neengcamango ezingacacanga).

ukusabela kwe-anaphylactic

Ukusabela komzimba okubangelwa yi-amoxicillin kunokulindela into engalindelekanga kunye nobunzima, kwaye unyango kufuneka lufunwe ngokukhawuleza. Olu hlobo lokusabela luhlala luqala ngotshintsho lwengqondo kwinqanaba lokuqala, lulandelwa kukurhawuzelela kolusu okukhatshwa kukurhawuzelelwa ngamandla (okudla ngokuqala kwiincam zeminwe kunye nokujikeleza kwegroin nokusasazeka ngokukhawuleza), ukuvutha komsindo, isicaphucaphu kunye nokugabha. Naziphi na ezinye iimpawu ezingabonakali nokukrokra kufuneka zijongwe nzulu.

I-Amoxicillin ayiyiyo irhashalala yolusu.

I-3-10% yabantwana bathatha i-amoxicillin (okanye i-ampicillin) kwaye bafumane i-rash (iiyure ezingama-72 emva kokuthatha i-penicillin), kodwa ingenzeka nakubantu abadala. Ngamanye amaxesha kuthiwa "i-amoxicillin rash".

Irhashalala ichazwa njengerhashalala ye-maculopapular okanye imasisi (efana nemasisi), ke ibizwa ngokuba "yimasisi-efana nerhashalala eyenziwa yi-amoxicillin" kuncwadi lwezonyango. Iqala esiqwini kwaye isasazeka ukusuka apho. Ayiyonto yokwenyani yokwaliwa, kwaye akukho mfuneko yokuyeka isicwangciso sonyango lwangoku. Nangona kunjalo, le rash ixhaphakileyo ye-amoxicillin kunye ne-aleji eyingozi ihlala ingabilula ukwahlula.

Irhashalala ye-amoxicillin engeyiyo i-allergic inokuba luphawu lwe-mononucleosis esosulelayo. Olunye uphononongo lubonisa ukuba malunga ne-80-90% yezigulane ziya kukhula le rhashalala xa zosulelwe yintsholongwane ye-EB ebukhali kwaye zinyangwe nge-amoxicillin okanye i-ampicillin.